Cajal bodies and snRNPs - friends with benefits. Issue 6 (3rd June 2017)

• Record Type: Journal Article
• Authors: Staněk, David
• Is Part Of: RNA biology. Volume 14:Issue 6(2017)
• Page Start: 671
• Page End: 679
• Publication Date: 2017-06-03
• Subjects: RNA -- Periodicals; Molecular biology -- Periodicals; Molecular biology; RNA; Periodicals; 572.8805
• DOI: 10.1080/15476286.2016.1231359
• Languages: English
• ISSNs: 1547-6286

Abstract

ABSTRACT: Spliceosomal snRNPs are complex particles that proceed through a fascinating maturation pathway. Several steps of this pathway are closely linked to nuclear non-membrane structures called Cajal bodies. In this review, I summarize the last 20 y of research in this field. I primarily focus on snRNP biogenesis, specifically on the steps that involve Cajal bodies. I also evaluate the contribution of the Cajal body in snRNP quality control and discuss the role of snRNPs in Cajal body formation.