Critical histone post-translational modifications for centromere function and propagation. Issue 13 (3rd July 2017)

• Record Type: Journal Article
• Authors: Fukagawa, Tatsuo
• Is Part Of: Cell cycle. Volume 16:Issue 13(2017)
• Page Start: 1259
• Page End: 1265
• Publication Date: 2017-07-03
• Subjects: centromere -- CENP-A -- histone modification -- kinetochore; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2017.1325044
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: The centromere is a critical genomic region that enables faithful chromosome segregation during mitosis, and must be distinguishable from other genomic regions to facilitate establishment of the kinetochore. The centromere-specific histone H3-variant CENP-A forms a special nucleosome that functions as a marker for centromere specification. In addition to the CENP-A nucleosomes, there are additional H3 nucleosomes that have been identified in centromeres, both of which are predicted to exhibit specific features. It is likely that the composite organization of CENP-A and H3 nucleosomes contributes to the formation of centromere-specific chromatin, termed 'centrochromatin'. Recent studies suggest that centrochromatin has specific histone modifications that mediate centromere specification and kinetochore assembly. We use chicken non-repetitive centromeres as a model of centromeric activities to characterize functional features of centrochromatin. This review discusses our recent progress, and that of various other research groups, in elucidating the functional roles of histone modifications in centrochromatin.