Advanced glycation endproducts (AGEs) in saliva of patients with multiple myeloma – a pilot study. Issue 12 (2nd December 2017)

• Record Type: Journal Article
• Authors: Katz, Joseph; Moreb, Jan; Baitinger, Catherine; Singer, Christine; Caudle, Robert M.
• Is Part Of: Leukemia & lymphoma. Volume 58:Issue 12(2017)
• Page Start: 2934
• Page End: 2938
• Publication Date: 2017-12-02
• Subjects: RAGE -- advanced glycation endproducts -- multiple myeloma -- saliva -- oxidative stress; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2017.1344845
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Multiple myeloma (MM) is a hematological cancer with underlying causes associated with increased oxidative stress. Through signaling of their receptor RAGE, advanced glycation endproducts (AGEs) are known to increase oxidative stress associated with malignant transformation. In the present study, we have demonstrated that the levels of these compounds are increased in the saliva of myeloma patients with bone lesions. This data may provide a potential marker for bone lesions in MM and a potential target for the treatment of myeloma by blocking the AGEs or their receptor.