Ascitic fluid drainage using a peritoneal dialysis catheter to prevent and treat multi‐organ dysfunction in veno‐occlusive disease in children undergoing hematopoietic stem cell transplantation. Issue 9 (28th February 2017)

• Record Type: Journal Article
• Authors: Parmar, Vijal; Lewis, Malcolm; Shenoy, Mohan; Bonney, Denise; Wynn, Robert
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 9(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-28
• Subjects: acute kidney injury -- hematopoietic stem cell transplantation -- multi‐organ failure -- peritoneal dialysis catheter -- veno‐occlusive disease; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26469
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Veno‐occlusive disease (VOD), or sinusoidal obstruction syndrome, is a well‐recognised, serious complication associated with the chemotherapy conditioning therapy used in hematopoietic stem cell transplantation (HSCT). Fluid management is typically challenging in children with this condition. We describe effective early use of peritoneal dialysis catheters to drain extravascular, intra‐abdominal fluid in children with VOD, allowing intravascular fluid administration to preserve renal perfusion and function, preventing multi‐organ dysfunction. All but one of the children are long‐term survivors, both of their significant VOD and their HSCT. The child that did not survive died from their underlying metabolic illness, not VOD.