Concurrent myeloid sarcoma, atypical teratoid/rhabdoid tumor, and hypereosinophilia in an infant with a germline SMARCB1 mutation. Issue 9 (23rd January 2017)

• Record Type: Journal Article
• Authors: Metts, Jonathan L.; Park, Sunita I.; Soares, Bruno P.; Fong, Cindy; Biegel, Jaclyn A.; Goldsmith, Kelly C.
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 9(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-01-23
• Subjects: brain tumors -- eosinophilia -- myeloid sarcoma -- SMARCB1; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26460
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: We report a 1‐year‐old female child presenting with hypereosinophilia who was found to have concurrent myeloid sarcoma and a central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT). She was later found to have a germline mutation in SMARCB1. Concurrent hematologic malignancy and CNS AT/RT have not previously been described in the context of a SMARCB1 loss‐of‐function germline mutation.