Assessment of CASP10 contact‐assisted predictions. (17th October 2013)

• Record Type: Journal Article
• Authors: Taylor, Todd J.; Bai, Hongjun; Tai, Chin‐Hsien; Lee, Byungkook
• Is Part Of: Proteins. Volume 82(2014)Supplement 2
• Page Start: 84
• Page End: 97
• Publication Date: 2013-10-17
• Subjects: protein structure prediction -- CASP10 -- contact assisted -- hybrid prediction; Proteins -- Periodicals; Proteins -- Periodicals; 572.6
• DOI: 10.1002/prot.24367
• Languages: English
• ISSNs: 0887-3585

Abstract

ABSTRACT: In CASP10, for the first time, contact‐assisted structure predictions have been assessed. Sets of pairs of contacting residues from target structures were provided to predictors for a second round of prediction after the initial round in which they were given only sequences. The objective of the experiment was to measure model quality improvement resulting from the added contact information and thereby assess and help develop so‐called hybrid prediction methods—methods where some experimentally determined distance constraints are used to augment de novo computational prediction methods. The results of the experiment were, overall, quite promising. Proteins 2014; 82(Suppl 2):84–97. © 2013 Wiley Periodicals, Inc.