Simplified staging laparotomy in FIGO stage 1 epithelial ovarian cancer: Follow-up and outcomes in South Wales, UK. (November 2013)

• Record Type: Journal Article
• Authors: Beena, A.; Howells, R.; Lutchman-Singh, K.; Dhar, K.; Lim, K.; Jones, R.; Hudson, E.; Bertelli, G.
• Is Part Of: Journal of obstetrics and gynaecology. Volume 33:Number 8(2013)
• Page Start: 888
• Page End: 891
• Publication Date: 2013-11
• Subjects: Epithelial ovarian cancer -- stage 1 ovarian cancer -- 5-year survival rate; Obstetrics -- Periodicals; Gynecology -- Periodicals; 618.05
• DOI: 10.3109/01443615.2013.834305
• Languages: English
• ISSNs: 0144-3615

Abstract

Abstract : We have conducted a retrospective analysis of FIGO stage 1 ovarian cancer patients in South Wales, who underwent a simplified staging laparotomy without routine nodal sampling and peritoneal biopsies. Patient records from January 2004 to December 2010 were analysed. A total of 116 patients were included in the final analysis. Adjuvant chemotherapy was offered to patients with risk factors for relapse (grade > 1, clear cell histology, or stage > Ia); overall, 89 patients (76.7%) received adjuvant single agent carboplatin ( n = 54, 46.5%) or combination chemotherapy ( n = 35, 30.2%). After a median follow up of 41 months (range 12–95), 18 patients have relapsed (15.5%), of these 17 had risk factors and 16 had received adjuvant chemotherapy. Eighteen patients have died, of whom 6 of non-cancer related causes without prior relapse. 5-year overall and relapse free survival were 80%. In conclusion, in situations where there are limited resources and operating time constraints, our data suggest that a simplified staging laparotomy approach may be a reasonable compromise in apparently early stage ovarian cancer: this may result in a more aggressive use of chemotherapy, but survival outcomes seem comparable to other series.