Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma?. Issue 4 (August 2017)

• Record Type: Journal Article
• Authors: Sripa, Banchob; Deenonpoe, Raksawan; Brindley, Paul J.
• Is Part Of: Parasitology international. Volume 66:Issue 4(2017:Aug.)
• Page Start: 383
• Page End: 389
• Publication Date: 2017-08
• Subjects: Liver fluke -- Opisthorchis viverrini -- Helicobacter spp. -- Co-infection -- Pathogenesis -- Hepatobiliary diseases -- Cholangiocarcinoma; Parasitology -- Periodicals; Parasites -- Periodicals; Parasitic Diseases -- Periodicals; Parasitology -- Periodicals; Parasitologie -- Périodiques; 571.99905
• DOI: 10.1016/j.parint.2016.11.016
• Languages: English
• ISSNs: 1383-5769

Abstract

Abstract: Infection with the fish-borne liver fluke Opisthorchis viverrini is classified by the International Agency for Research on Cancer as a Group 1 carcinogen: definitely carcinogenic in humans. Cofactors likely contribute to bile duct cancer (cholangiocarcinoma) caused by this infection. Here we review recent findings that address the role of liver fluke associated H . pylori in hepatobiliary disease and malignancy. We hypothesize that co-infection by O . viverrini and the bacillus Helicobacter pylori is central of liver fluke infection associated cholangiocarcinoma. Graphical abstract: Highlights: Opisthorchis / Helicobacter co-infection is central to opisthorchiasis. Opisthorchis is a reservoir of H . pylori . H . pylori may play key role in pathogenesis of opisthorchiasis-induced cholangiocarcinoma.