Hydroxylated 2-Ethylhexyl tetrabromobenzoate isomers in house dust and their agonistic potencies with several nuclear receptors. (August 2017)

• Record Type: Journal Article
• Authors: Peng, Hui; Sun, Jianxian; Saunders, David M.V.; Codling, Garry; Wiseman, Steve; Jones, Paul D.; Giesy, John P.
• Is Part Of: Environmental pollution. Volume 227(2017)
• Page Start: 578
• Page End: 586
• Publication Date: 2017-08
• Subjects: Brominated flame retardants -- OH-TBB -- Firemaster® 550 -- BZ-54 -- PPARγ; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2017.04.094
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: In the current study, by combining ultra-high resolution (UHR) MS 1 spectra, MS 2 spectra, and derivatization, three hydroxylated isomers of 2-ethylhexyl tetrabromobenzoate (OH-TBB) were identified in Firemaster ® 550 and BZ-54 technical products. Also, a new LC-UHRMS method, using atmospheric pressure chemical ionization (APCI), was developed for simultaneous analysis of OH-TBB, TBB, hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) and TBPH in 23 samples of dust collected from houses in Saskatoon, SK, Canada. OH-TBBs were detected in 91% of samples, with a geometric mean concentration of 0.21 ng/g, which was slightly less than those of OH-TBPH (0.35 ng/g). TBB was detected in 100% of samples of dust with a geometric mean concentration of 992 ng/g. Significant ( p < 0.001) log-linear relationships between concentrations of OH-TBBs, TBB, or OH-TBPHs and TBPH in dust support the hypothesis of a common source of these compounds. OH-TBBs were found to be strong agonists of peroxisome proliferator-activated receptor gamma (PPARγ) and weaker agonists of the estrogen receptor (ER), but no agonistic potencies was observed with the androgen receptor (AR). Occurrence of OH-TBBs in technical products and house dust, together with their relatively strong PPARγ potencies, indicated their potential risk to health of humans. Graphical abstract: Highlights: Novel OH-TBB isomers were identified in technical products and house dusts. A new APCI method was established for simultaneous analysis of TBB and OH-TBB. OH-TBB was weak ER agonist but relatively strong PPARγ agonist. Abstract : Novel hydroxylated isomers of 2-ethylhexyl tetrabromobenzoate (OH-TBB) were identified in house dust, with stronger nuclear receptor agonistic activities than native OH-TBB.