Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis. (3rd July 2017)

• Record Type: Journal Article
• Authors: Barrie, Amy; Homburg, Roy; McDowell, Garry; Brown, Jeremy; Kingsland, Charles; Troup, Stephen
• Is Part Of: Human fertility. Volume 20:Number 3(2017)
• Page Start: 179
• Page End: 185
• Publication Date: 2017-07-03
• Subjects: IVF -- time-lapse -- EmbryoScope -- matched-pair; Fertility, Human -- Periodicals; Infertility -- Periodicals; 616.692
• DOI: 10.1080/14647273.2016.1258735
• Languages: English
• ISSNs: 1464-7273

Abstract

Abstract: A retrospective strict matched-pair analysis of 728 treatment cycles between January 2011 and September 2014 was performed. A total of 364 treatment cycles, where all embryos were cultured and examined in EmbryoScope ®, were matched to treatment cycles where all the embryos were cultured in a standard incubator with conventional morphological examination. Matching was performed for patient age, number of oocytes collected, treatment type and date of oocyte collection (± six months). The clinical (CPR), implantation (IR), live birth (LBR) and miscarriage rates (MR) were calculated and considered significant when p < 0.05 (Chi-square test). CPR, IR and LBR were found to be significantly higher in the time-lapse system (TLS) group compared to the standard incubation group (CPR = 44.8% versus 36.5%, p = 0.02; IR = 39.3% versus 32.2%, p = 0.03; and LBR = 43.1% versus 33.8%, p = 0.01). Although there was a 5.5% decrease in the MR for the TLS group when compared to the standard incubation group, this result was not statistically significant (18.9% versus 24.4%, p = 0.19). There is a paucity of well-designed studies to confirm that embryos cultured and examined in TLS can result in superior treatment outcomes, and this strict-matched pair analysis with a large cohort of treatment cycles indicates the advantage of using TLS.