Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson's disease in differentiated SH-SY5Y cells. Issue 8 (3rd August 2017)

• Record Type: Journal Article
• Authors: Hao, Xin-Mei; Li, Lian-Da; Duan, Chang-Ling; Li, Yu-Juan
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 8(2017)
• Page Start: 833
• Page End: 845
• Publication Date: 2017-08-03
• Subjects: α-Mangostin -- Parkinson's disease -- mitochondrial dysfunction -- α-synuclein -- rotenone; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1339349
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: The study was designed to evaluate the protective effect of α-mangostin and explore its mechanism in an in vitro model of Parkinson's disease (PD) induced by rotenone. SH-SY5Y cells were treated with rotenone and α-mangostin for 24 h. α-Mangostin significantly and concentration-dependently inhibited rotenone-induced cytotoxicity. The rotenone-induced aggregation of α-synuclein and loss of TH were alleviated by α-mangostin. α-Mangostin treatment also reversed the rotenone-induced overproduction of reactive oxygen species, activation of caspases (−8 and −3) and mitochondrial dysfunction, reflected by decrease in mitochondrial membrane potential and cellular ATP levels. These findings suggest that α-mangostin has neuroprotective effects against PD-related neuronal injury. Abstract :