Synthesis and bioactivity evaluation of some novel sulfonamide derivatives. (3rd July 2017)

• Record Type: Journal Article
• Authors: Subramanyam, Ch.; Nayab Rasool, Sk.; Janakiramudu, D. B.; Rasheed, S.; Uday Sankar, A.; Naga Raju, C.
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 192:Number 7(2017)
• Page Start: 845
• Page End: 849
• Publication Date: 2017-07-03
• Subjects: Sulfonamide derivatives -- antibacterial activity -- antifungal activity -- antioxidant activity; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2017.1288123
• Languages: English
• ISSNs: 1042-6507

Abstract

GRAPHICAL ABSTRACT: ABSTRACT: A simple and convenient method for the synthesis of biologically active sulfonamide derivatives was achieved. All the title compounds were characterized by spectral and elemental analysis. They were further screened in vitro for their abilities towards antibacterial, antifungal and antioxidant activities. The compound N, N' -(3, 3′-dimethoxybiphenyl-4, 4′-diyl)bis(4-fluorobenzenesulfonamide) (5b ) and N -(3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)-4-fluoro-N-isopropylbenzenesulfonamide (5e ) exhibited good activity when compared to the standard bactericide, Chloramphenicol and fungicide, Ketoconazole respectively. The compounds (2S)- N -((2S, 4S)-5-(4-Chloro-phenylsulfonamido)-4-hydroxy-1, 6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrim-idin-1(2H)-yl)butan-amide (4f ) and (2S)- N -((2S, 4S)-5-(4-fluorophenylsulfonamido)-4-hydroxy-1, 6-diphenyl-hexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)bu-tana-mide (5f ) exhibited good antioxidant activity when compared with standard antioxidant, Ascorbic acid.