5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1–3 (TET1–3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. (3rd April 2017)

• Record Type: Journal Article
• Authors: Chamessian, Alexander G.; Qadri, Yawar J.; Cummins, Matthew; Hendrickson, Michele; Berta, Temugin; Buchheit, Thomas; Van de Ven, Thomas
• Is Part Of: Somatosensory & motor research. Volume 34:Number 2(2017)
• Page Start: 72
• Page End: 79
• Publication Date: 2017-04-03
• Subjects: Chronic pain -- epigenetics -- neuropathic pain; Skin -- Innervation -- Periodicals; Somesthesia -- Periodicals; Perceptual-motor processes -- Periodicals; 573.85
• DOI: 10.1080/08990220.2017.1292237
• Languages: English
• ISSNs: 0899-0220

Abstract

Abstract: Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase following nerve injury. Furthermore, we show that the 5hmC-generating Ten-eleven translocation 1–3 (TET1–3) proteins are expressed in a cell-type specific manner in the DRG, with Tet3 displaying differential upregulation after injury, suggesting a potential role in neuropathic pain.