Copper(ii) catalyzed iodine-promoted oxidative cyclization of 2-amino-1, 3, 5-triazines and chalcones: synthesis of aroylimidazo[1, 2-a][1, 3, 5]triazines. Issue 26 (22nd June 2017)

• Record Type: Journal Article
• Authors: Li, Jin Jing; Song, Chan; Cui, Dong-Mei; Zhang, Chen
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 26(2017)
• Page Start: 5564
• Page End: 5570
• Publication Date: 2017-06-22
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01018d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient method for the synthesis of aroylimidazo[1, 2- a ][1, 3, 5]triazine derivatives based on a copper(ii ) catalyzed iodine-promoted reaction of 2-amino-1, 3, 5-triazines and chalcones is presented. Abstract : An efficient copper(ii ) catalyzed iodine-promoted synthesis of aroylimidazo[1, 2- a ][1, 3, 5]triazines from 2-amino-1, 3, 5-triazines and chalcones under mild conditions has been developed. The reaction occurred with good yields and excellent regioselectivities, and tolerated chalcone containing functionalities such as ethers, halogens, and nitro groups. The successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.