Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels–Alder and ene-reactions. Issue 26 (22nd June 2017)

• Record Type: Journal Article
• Authors: Brossard, Dominique; Retailleau, Pascal; Dumontet, Vincent; Breton, Philippe; Desrat, Sandy; Roussi, Fanny
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 26(2017)
• Page Start: 5585
• Page End: 5592
• Publication Date: 2017-06-22
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01236e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Thermic dimerization of methyl 1, 3-cyclohexadiene 2-carboxylate gave original 3D-shape compounds by Diels–Alder cycloaddition and original [6 + 4]-ene reaction. Abstract : Thermic dimerization of methyl 1, 3-cyclohexadiene 2-carboxylate gave original 3D-shape compounds by Diels–Alder cycloaddition and original [6 + 4]-ene reaction. Further selective modifications on an endo [4 + 2] cycloadduct via a diversity oriented synthesis (DOS) strategy quickly led to the preparation of a small library of original 3D scaffolds, providing access to a larger and unexplored chemical space for drug discovery processes.