Species‐specific impact of the autophagy machinery on Chikungunya virus infection. (26th April 2013)

• Record Type: Journal Article
• Authors: Judith, Delphine; Mostowy, Serge; Bourai, Mehdi; Gangneux, Nicolas; Lelek, Mickaël; Lucas‐Hourani, Marianne; Cayet, Nadège; Jacob, Yves; Prévost, Marie‐Christine; Pierre, Philippe; Tangy, Frédéric; Zimmer, Christophe; Vidalain, Pierre‐Olivier; Couderc, Thérèse; Lecuit, Marc
• Is Part Of: EMBO reports. Volume 14:Number 6(2013)
• Page Start: 534
• Page End: 544
• Publication Date: 2013-04-26
• Subjects: autophagy -- Chikungunya virus -- p62 -- NDP52 -- species specificity; Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.1038/embor.2013.51
• Languages: English
• ISSNs: 1469-221X

Abstract

Abstract : Chikungunya virus (CHIKV) is a recently re‐emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52—but not its mouse orthologue—interacts with the non‐structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity. Species‐specific impact of the autophagy machinery on Chikungunya virus infection: CHIKV interacts with the autophagy machinery, inducing a cytoprotective effect. In addition, binding to the human—but not mouse—autophagy receptor NDP52 promotes viral replication. This explains CHIKV species specificity and could help engineer a mouse model of infection.