Genetically engineered mouse models of melanoma. (1st June 2017)

• Record Type: Journal Article
• Authors: Pérez‐Guijarro, Eva; Day, Chi‐Ping; Merlino, Glenn; Zaidi, M. Raza
• Is Part Of: Cancer. Volume 123(2017)Supplement S11
• Page Start: 2089
• Page End: 2103
• Publication Date: 2017-06-01
• Subjects: carcinogen -- genetically engineered mice -- melanoma -- mouse models -- ultraviolet (UV) radiation; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.30684
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089‐103 . © 2017 American Cancer Society . Abstract : A general overview of genetically engineered mouse modeling and a comprehensive review of the currently available mouse models of melanoma are provided. The basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of genetically engineered mouse models in melanoma are described.