Drug Delivery: Nanoengineered Particles for Enhanced Intra‐Articular Retention and Delivery of Proteins (Adv. Healthcare Mater. 10/2014). Issue 10 (October 2014)

• Record Type: Journal Article
• Authors: Singh, Ankur; Agarwal, Rachit; Diaz‐Ruiz, Carlos A.; Willett, Nick J.; Wang, Peiyi; Lee, L. Andrew; Wang, Qian; Guldberg, Robert E.; García, Andrés J.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 10(2014:Oct.)
• Page Start: 1561
• Page End: 1561
• Publication Date: 2014-10
• Subjects: nanoparticles -- osteoarthritis -- protein delivery -- biomaterials; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201470051
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Localized intra‐articular delivery of anti‐inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of rapid clearance within few hours of injection. On page 1562, A. J. García and co‐workers report a new class of polymer that forms self‐assembled nanoparticles with therapeutic proteins for prolonged retention in intra‐articular joint spaces compared to bolus protein doses.