Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights. Issue 7 (26th June 2017)

• Record Type: Journal Article
• Authors: Masschelein, J.; Jenner, M.; Challis, G. L.
• Is Part Of: Natural product reports. Volume 34:Issue 7(2017)
• Page Start: 712
• Page End: 783
• Publication Date: 2017-06-26
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c7np00010c
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : Gram-negative bacteria are a rich and underexplored source of antibiotics that are assembled via remarkably diverse biosynthetic pathways. Abstract : Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have become increasingly recognised as a rich yet underexplored source of novel antimicrobials, with the potential to combat the looming health threat posed by antibiotic resistance. In this article, we have compiled a comprehensive list of natural products with antimicrobial activity from Gram-negative bacteria, including information on their biosynthetic origin(s) and molecular target(s), where known. We also provide a detailed discussion of several unusual pathways for antibiotic biosynthesis in Gram-negative bacteria, serving to highlight the exceptional biocatalytic repertoire of this group of microorganisms.