Amide-assisted radical strategy: metal-free direct fluorination of arenes in aqueous media. Issue 14 (20th June 2017)

• Record Type: Journal Article
• Authors: Liang, Deqiang; Li, Yanni; Gao, Shulin; Li, Renlun; Li, Xiangguang; Wang, Baoling; Yang, Hai
• Is Part Of: Green chemistry. Volume 19:Issue 14(2017)
• Page Start: 3344
• Page End: 3349
• Publication Date: 2017-06-20
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c7gc00356k
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A practical aromatic C–H fluorination. Abstract : A metal- and initiator-free direct fluorination of arenes with the assistance of an amide group is developed. This reaction proceeded under simple aqueous conditions with good functional group tolerance and ortho – para selectivity, and is highly practical because it could be readily scaled up to a multigram-scale. At this stage, an exclusive mechanism could not be proposed, and several possibilities have been discussed. The possibility of the amide-assisted radical chain mechanism has been supported by experimental and computational investigations as well as a seminal work.