An N-heterocyclic carbene iridium catalyst with metal-centered chirality for enantioselective transfer hydrogenation of imines. Issue 57 (5th July 2017)

• Record Type: Journal Article
• Authors: Li, Yanjun; Lei, Meng; Yuan, Wei; Meggers, Eric; Gong, Lei
• Is Part Of: Chemical communications. Volume 53:Issue 57(2017)
• Page Start: 8089
• Page End: 8092
• Publication Date: 2017-07-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc04691j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A cyclometalating N-heterocyclic carbene iridium complex featuring metal-centered chirality has been developed for the highly enantioselective transfer hydrogenation of imines. Abstract : A cyclometalating N-heterocyclic carbene iridium complex featuring metal-centered chirality was designed and used for the asymmetric transfer hydrogenation (ATH) of imines. Four strongly σ-donating carbon-based substituents (2 carbenes and 2 phenyl moieties), a chirality transfer directly from the stereogenic metal center to the CN bond of substrates, as well as a restriction of catalyst deactivation by steric demanding substituents, render the new complex one of the most efficient catalysts for ATH of cyclic N -sulfonylimines (down to 0.01 mol% cat., 24 examples, 94–98% ee).