Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis. Issue 56 (29th June 2017)

• Record Type: Journal Article
• Authors: Williams, Katherine; Szwalbe, Agnieszka J.; Dickson, Claire; Desson, Tim R.; Mulholland, Nicholas P.; Vincent, Jason L.; Clough, John M.; Bailey, Andrew M.; Butts, Craig P.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J.
• Is Part Of: Chemical communications. Volume 53:Issue 56(2017)
• Page Start: 7965
• Page End: 7968
• Publication Date: 2017-06-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc03303f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The biosynthetic gene cluster for the selective herbicide cornexistin1 from the fungus Paecilomyces variotii has been identified and analysed. Abstract : The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.