Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study. Issue 1 (July 2017)

• Record Type: Journal Article
• Authors: Cheng, Ran; Ma, Yaxian; Nie, Ying; Qiao, Xiaoyong; Yang, Zhilan; Zeng, Rujun; Xu, Liangzhi
• Is Part Of: Reproductive biomedicine online. Volume 35:Issue 1(2017)
• Page Start: 72
• Page End: 80
• Publication Date: 2017-07
• Subjects: chromosomal polymorphism -- female infertility -- preterm birth -- spontaneous miscarriage; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2017.03.022
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: Data from 19, 950 women were retrospectively analysed to determine the effect of chromosomal polymorphisms on female infertility and pregnancy outcome; fertile women were used as controls. Frequency of chromosomal polymorphisms and adverse pregnancy outcomes were compared between groups. A significantly higher incidence of chromosomal polymorphisms was found in total infertile patients, and patients with tubal infertility, ovulatory dysfunction, cervical and uterine abnormalities, and unexplained infertility compared with controls (5.53% [ P < 0.001], 4.86% [ P = 0.012] 5.40% [ P < 0.001], 5.75% [ P < 0.001] and 8.51% [ P < 0.001], versus 3.74%, respectively). Infertile women had a higher incidence of 9qh+ and inv(9) compared with controls ( P < 0.001 and P = 0.027). Logistic regression analysis showed an effect of chromosomal polymorphisms on female infertility (adjusted OR 1.662, 95% CI 1.551 to 1.796, P < 0.001). All couples reported a phenotypically normal baby. In control and tubal infertility groups, miscarriage rates were higher in women with chromosomal polymorphisms than in women with normal chromosomes (4.95% versus 0.96%, P = 0.001 and 6.17% versus 1.08%, P < 0.001). Preterm birth rate showed a similar trend. Chromosomal polymorphisms adversely affected spontaneous miscarriage rates (adjusted OR 1.625, 95% CI 1.514 to 1.769, P = 0.005).