Copper-catalyzed cascade annulation of unsaturated α-bromocarbonyls with enynals: a facile access to ketones from aldehydes. Issue 7 (16th March 2016)

• Record Type: Journal Article
• Authors: Che, Chao; Huang, Qianwen; Zheng, Hanliang; Zhu, Gangguo
• Is Part Of: Chemical science. Volume 7:Issue 7(2016:Jul.)
• Page Start: 4134
• Page End: 4139
• Publication Date: 2016-03-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5sc04980f
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A Cu-catalyzed cascade annulation of enynals with alkenyl or alkynyl α-bromocarbonyls for the synthesis of various cyclohexenone-fused polycyclic compounds is described. Abstract : A Cu-catalyzed cascade annulation of enynals with alkenyl or alkynyl α-bromocarbonyls for the synthesis of various cyclohexenone-fused polycyclic compounds is described. Up to six new C–C bonds and four new carbocycles can be established in a single reaction, highlighting the high efficiency and step-economics of this protocol. This reaction offers a novel and straightforward entry to the synthesis of ketones featuring the addition of carbon radicals to aldehydes.