Characteristics of pediatric invasive pneumococcal diseases and the pneumococcal isolates in Suzhou, China before introduction of PCV13. Issue 33 (24th July 2017)

• Record Type: Journal Article
• Authors: Zhang, Xiyan; Tian, Jianmei; Shan, Wei; Xue, Jian; Tao, Yunzhen; Geng, Qian; Ding, Yunfang; Zhao, Genming; Zhang, Tao
• Is Part Of: Vaccine. Volume 35:Issue 33(2017)
• Page Start: 4119
• Page End: 4125
• Publication Date: 2017-07-24
• Subjects: Streptococcus pneumoniae -- Invasive pneumococcal disease -- Children -- Suzhou; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2017.06.046
• Languages: English
• ISSNs: 0264-410X

Abstract

Highlights: Pediatric IPD patients had severe symptoms, intensive treatment, poor prognosis and heavy burden. The most common serotypes of the IPD isolates were serotype 6B and 14. The coverage of PCV13 serotypes was 92.5%. Introduction of PCV13 may ease the burden of IPD in China. Abstract: Background: Data on characteristics of invasive pneumococcal diseases (IPD) is limited in China. We aimed to understand the clinical features and explore the molecular characteristics of the pneumococcal isolates in China. Methods: Since 2010, we prospectively collected the pneumococcal isolates and the IPD patients' demographic and clinical information in Suzhou University Affiliated Children's Hospital (SCH). The antibiotic susceptibility, serotypes, genotypes of Streptococcus pneumoniae strains were identified by E-test, quellung reaction and/or multiplex PCR, and multi-locus sequence typing, respectively. Results: During the period from January 2010 to December 2015, a total of 80 IPD patients were identified. They were diagnosed as meningitis (31.3%), septicemia (27.5%), pneumonia (21.3%) and others (20.0%). About half of them required vancomycin treatment, 42.5% were admitted to ICUs, 36.2% had complications and 6.2% were hospitalized for over 1 year. The most common serotypes of the pneumococcal isolates were serotypes 6B and 14, the coverage of PCV13 was 92.5%, and CC236s and CC199s were the most common clone complexes. Conclusions: Pediatric IPD patients had severe clinical symptoms, demanded intensive treatment, suffered poor prognosis and substantial burden. The pneumococcal isolates' serotype coverage of PCV13 vaccine was high, which leads to implication of PCV vaccine usage among children in China.