Oleic acid-derived oleoylethanolamide: A nutritional science perspective. (July 2017)

• Record Type: Journal Article
• Authors: Bowen, Kate J.; Kris-Etherton, Penny M.; Shearer, Gregory C.; West, Sheila G.; Reddivari, Lavanya; Jones, Peter J.H.
• Is Part Of: Progress in lipid research. Volume 67(2017:Jul.)
• Page Start: 1
• Page End: 15
• Publication Date: 2017-07
• Subjects: ABHD4 α/β-hydrolase domain-containing protein 4 -- AEA arachidonoylethanolamide -- A:G android-to-gynoid -- CHO carbohydrate -- DHEA docosahexaenoylethanolamide -- DXA dual-energy X-ray absorptiometry -- E energy -- EEA elaidoylethanolamide -- FAAH fatty acid amide hydrolase -- FABP fatty acid binding protein -- FAT/CD36 fatty acid translocase/cluster of differentiation 36 -- FFA free fatty acid -- GDE glycerophosphodiesterase -- GP-NAE glycerophospho-N-acylethanolamine -- high-OA high-oleic acid -- high-PA high-palmitic acid -- INSIG-1 insulin induced gene-1 -- IP intraperitoneal -- LEA linoleoylethanolamide -- L-FABP liver fatty acid binding protein -- MUFA monounsaturated fatty acid -- NAAA N-acylethanolamine-hydrolyzing acid amidase -- NAE N-acylethanolamine -- NAPE N-acylphosphatidylethanolamine -- NAPE-PLD NAPE-specific phospholipase D -- NAT N-acyltransferase -- NEFA non-esterified fatty acid -- NOPE N-oleoyl-phosphatidylethanolamine -- OEA oleoylethanolamide -- PEA palmitoylethanolamide -- PLC phospholipase C -- PPAR-α peroxisome proliferator-activated receptor α -- PUFA polyunsaturated fatty acid -- sPLA2 secretory phospholipase A2 -- SFA saturated fatty acid -- SNP single nucleotide polymorphism -- TRPV1 transient receptor potential vanilloid type-1 -- T2D Type 2 Diabetes -- UCP uncoupling protein -- UF:LF upper fat-to-lower fat -- VEA vaccinoylethanolamide; Body composition -- Dietary fat -- Lipid metabolism -- N-acylethanolamine -- Oleic acid -- Oleoylethanolamide; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipiden; 572.57
• DOI: 10.1016/j.plipres.2017.04.001
• Languages: English
• ISSNs: 0163-7827

Abstract

Abstract: The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Numerous clinical studies demonstrate a beneficial relationship between high-oleic acid diets and body composition, with emerging evidence to suggest OEA may mediate this response through modulation of lipid metabolism and energy intake. OEA exposure has been shown to stimulate fatty acid uptake, lipolysis, and β-oxidation, and also promote food intake control. Future research on high-oleic acid diets and body composition is warranted to confirm these outcomes and elucidate the underlying mechanisms by which oleic acid exerts its biological effects. These findings have significant practical implications, as the oleic acid-derived OEA molecule may be a promising therapeutic agent for weight management and obesity treatment.