Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease. Issue 4 (August 2017)

• Record Type: Journal Article
• Authors: Rosendahl Madsen, A.M.; Holm, A.; Jensen, T.G.; Knudsen, E.; Lundgaard, H.; Skov, M.N.; Uldum, S.A.; Kemp, M.
• Is Part Of: Journal of hospital infection. Volume 96:Issue 4(2017)
• Page Start: 392
• Page End: 395
• Publication Date: 2017-08
• Subjects: Legionella -- Nosocomial infection -- Whole-genome sequencing; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2017.04.020
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease.