Adiponectin: Its role in obesity-associated colon and prostate cancers. (August 2017)

• Record Type: Journal Article
• Authors: Muppala, Santoshi; Konduru, Siva K.P.; Merchant, Neha; Ramsoondar, Judy; Rampersad, Carlos Karan; Rajitha, Balney; Mukund, Vidya; Kancherla, Jyothsna; Hammond, Anthea; Barik, Tapan Kumar; Mannarapu, Mastan; Alam, Afroz; Basha, Riyaz; Bramhachari, Pallaval Veera; Verma, Dheeraj; Sushma, Pinninti Santosh; Pattnaik, Subasini; Nagaraju, Ganji Purnachandra
• Is Part Of: Critical reviews in oncology/hematology. Volume 116(2017)
• Page Start: 125
• Page End: 133
• Publication Date: 2017-08
• Subjects: Acrp30 Adipocyte complement related protein 30kda -- AdipoR1 Adiponectin receptor1 -- AdipoR2 Adiponectin receptor2 -- AdipoQ Adiponectin precursor -- APN Adiponectin -- AMPK Adenosine monophosphate activated protein kinase -- ADT Androgen deprivation therapy -- BMI Body mass index -- Bcl-2 B cell lymphoma 2 -- Bax Bcl2 associated X-protein -- BPH Benign prostatic hyperplasia -- CP Colonic polyps -- cAMP Cyclic adenosine monophosphate -- CI Confidence interval -- CRC Colorectal cancer -- EGFR Epithelial growth factor receptor -- GBP28 Gelatin binding protein 28kda -- HMW High molecular weight -- IBD Inflammatory bowel disease -- JNK Jun-amino terminal kinases -- LMW Low molecular weight -- OR Odd ratio -- PC Prostate cancer -- PCa Prostate cancer gene -- PIN Prostatic intraepithelial neoplasia -- PKA Protein kinase A -- PPAR-γ Peroxisome proliferator-activated receptor gamma -- PSA Prostate specific antigen -- RR Relative risk -- STAT3 Signal transducer and activator of transcription3 -- TNF-α Tumor necrosis factor-alpha; Obesity -- Adiponectin -- Adiponectin receptors -- Colorectal cancer -- Prostate cancer; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2017.06.003
• Languages: English
• ISSNs: 1040-8428

Abstract

Highlights: We review the role of adiponectin in obesity-linked colorectal and prostate cancer. We discuss the physiological and biological functions of adiponectin. We outline the role of adiponectin receptors in both colorectal and prostate cancer. We discuss adiponectin and its receptors as possible novel prognostic factors. Abstract: Adipose tissue synthesizes many proteins and hormones collectively called adipokines, which are linked to a number of diseases, including cancer. Low levels of adiponectin are reported to be a risk factor for obesity-related cancers including colorectal and prostate cancers. Accordingly, obesity/lifestyle-related diseases, including certain cancers, may be treated by developing drugs that act specifically on adiponectin levels in circulation. Adiponectin may also serve as a clinical biomarker in obesity-related diseases. Adiponectin-based therapies are known to inhibit cancer advancement and thus may provide a therapeutic approach to delay cancer progression. Better understanding of the function of adiponectin is of great significance in the fight against cancer. This timely review is concentrated on the role of adiponectin and the impact of obesity on the development of cancers, especially colorectal and prostate cancers.