Synthesis, spectroscopic characterization, crystal structure, and biological evaluation of a diorganotin(IV) complex with 2-acetylpyridine N4-cyclohexylthiosemicarbazone. Issue 6 (3rd June 2017)

• Record Type: Journal Article
• Authors: Liu, Taiyu; Sun, Jiayang; Tai, Yanxue; Qian, Hai; Li, Mingxue
• Is Part Of: Inorganic and nano-metal chemistry. Volume 47:Issue 6(2017)
• Page Start: 813
• Page End: 817
• Publication Date: 2017-06-03
• Subjects: Thiosemicarbazone -- diorganotin(IV) -- crystal structure -- cytotoxicity; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: 10.1080/15533174.2016.1219867
• Languages: English
• ISSNs: 2470-1556

Abstract

ABSTRACT: The diorganotin(IV) complex [Ph2 Sn(L)(OAc)]·EtOH (1), where HL = 2-acetylpyridine N 4 -cyclohexyl thiosemicarbazone, has been synthesized and characterized by elemental analysis, IR, UV–vis, NMR, PL, and mass spectrometry. The crystal structure was characterized by X-ray diffraction method. Tin(IV) ion is coordinated by one L − anion through pyridine nitrogen, azomethine nitrogen and sulfur atom, two phenyl groups, and one OAc − anion through two carboxyl oxygen atoms building a distorted pentagonal bipyramid. Biological studies showed that 1 exhibited lower IC50 value 3.32 ± 0.52 μM against HepG2 cells, compared to the free ligand. In addition, complex 1 also exhibited excellent luminescent property.