Signatures of DNA target selectivity by ETS transcription factors. Issue 3 (27th May 2017)

• Record Type: Journal Article
• Authors: Poon, Gregory M. K.; Kim, Hye Mi
• Is Part Of: Transcription. Volume 8:Issue 3(2017)
• Page Start: 193
• Page End: 203
• Publication Date: 2017-05-27
• Subjects: ETS transcription factors -- PU.1 -- Ets-1 -- molecular hydration -- phylogeny -- epigenetics -- DNA methylation; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2017.1302901
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. DNA target specificity derives from combinatorial interactions with other proteins as well as intrinsic heterogeneity among ETS domains. Emerging evidence suggests molecular hydration as a fundamental feature that defines the intrinsic heterogeneity in DNA target selection and susceptibility to epigenetic DNA modification. This perspective invokes novel hypotheses in the regulation of ETS proteins in physiologic osmotic stress, their pioneering potential in heterochromatin, and the effects of passive and pharmacologic DNA demethylation on ETS regulation.