Biomimetic Total Synthesis of (±)‐Homodimericin A. Issue 27 (5th June 2017)

• Record Type: Journal Article
• Authors: Ma, Donghui; Liu, Yangbin; Wang, Zhang
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 27(2017)
• Page Start: 7886
• Page End: 7889
• Publication Date: 2017-06-05
• Subjects: biomimetic synthesis -- cascade reactions -- homodimericin -- Negishi coupling -- total synthesis; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201702775
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A biomimetic total synthesis of racemic homodimericin A was achieved in seven steps, including two cascade reactions. Aqueous buffer solutions are found to help both the oxidative dimerization cascade and the intramolecular Diels–Alder cascade. This synthetic sequence validates key steps in the biogenetic proposal of homodimericin A. Abstract : Magnificent seven : The biomimetic synthesis of homodimericin A was accomplished in seven steps involving two cascade reactions. The biosynthesis proposal was validated with experimental support.