Iridium‐Catalyzed Formyl‐Selective Deuteration of Aldehydes. Issue 27 (7th June 2017) - Kerr, William J.
Abstract: We report the first direct catalytic method for formyl‐selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium‐based catalyst designed to favor formyl over aromatic C−H activation. A good range of aromatic aldehydes is selectively labeled, and a one‐pot labeling/olefination method is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways. Abstract : Al(D)hydes : An iridium catalyst system was designed to effect formyl over aryl C−H activation of aromatic aldehydes. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.