Cover Picture: Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation (ChemPhotoChem 6/2017). Issue 6 (12th June 2017)

• Record Type: Journal Article
• Authors: Tinklepaugh, Jay; Smith, Britannia M.; Nie, Yan; Moody, Kelsey; Grohn, Kris; Bou‐Abdallah, Fadi; Doyle, Robert P.
• Is Part Of: ChemPhotoChem. Volume 1:Issue 6(2017)
• Page Start: 254
• Page End: 254
• Publication Date: 2017-06-12
• Subjects: bisretinoids -- enzymatic oxidation -- macular degeneration -- photooxidation -- saposin B; Photochemistry -- Periodicals; Periodicals; Electronic journals; 541.35
• DOI: 10.1002/cptc.201700083
• Languages: English
• ISSNs: 2367-0932

Abstract

Abstract : The Front Cover picture illustrates lipofuscin bisretinoid A2E blue‐light‐induced photooxidation and its protection by the lysosomal protein Saposin B (SapB). Binding of A2E, a common bisretinoid found in granules in patients with age‐related macular degeneration, by SapB protects A2E from both enzymatic degradation and photooxidation by blue light. More information can be found in the Communication by R. P. Doyle and co‐workers onpage 256 in Issue 6, 2017 (DOI:10.1002/cptc.201700039 ).