A new insight into the ability to resist Ischemic brain injury: Does hibernation matter?: An Editorial comment for 'Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux'. Issue 1 (24th May 2017)

• Record Type: Journal Article
• Authors: Nathaniel, Thomas I.; Stewart, Bianca; Williams, Jessica; Hood, Michael; Imeh‐Nathaniel, Adebobola
• Is Part Of: Journal of neurochemistry. Volume 142:Issue 1(2017)
• Page Start: 10
• Page End: 13
• Publication Date: 2017-05-24
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.14022
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract : Read the commented article 'Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux' on doi: 10.1111/jnc.13996 . Abstract : In humans, the blockage of cerebral arteries causes a decrease in blood flow to the brain, resulting in ischemic injury. Moreover, reduced blood flow restricts delivery of nutrients such as glucose and removal of metabolic waste. In stroke patients, ischemic brain injury is a major medical issue. Much can be learned from a model system such as the Arctic ground squirrel (AGS) on how to resist brain damage. This Editorial discusses a new study by Bhowmick et al . (2017) published in the current issue of the Journal of Neurochemistry that reveals that AGS hippocampus tolerates oxygen glucose deprivation (OGD) injury, and that the influence of season on cerebral ischemia tolerance is inconsequential in AGS's ability to resist ischemic injury. The study provides insight into a model system with an adaptation to tolerate ischemic injury, and resist brain damage following cerebral ischemia/reperfusion. Read the commented article 'Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux' on page 160 .