Biocompatible Cup‐Shaped Nanocrystal with Ultrahigh Photothermal Efficiency as Tumor Therapeutic Agent. (21st April 2017)

• Record Type: Journal Article
• Authors: Gao, Fengli; Sun, Maozhong; Xu, Liguang; Liu, Liqiang; Kuang, Hua; Xu, Chuanlai
• Is Part Of: Advanced functional materials. Volume 27:Number 24(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04-21
• Subjects: gold nanocups -- phototherapy -- photothermal conversion efficiency -- tumor obliteration; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201700605
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : As an emerging treatment for cancer, phototherapy has received much clinical attention. Here, a multifunctional Au nanocup (Au NC) for the targeted computed tomographic and photoacoustic imaging of cancerous tumors and phototherapy is reported. The Au NC has an intrinsic photothermal conversion efficiency of 38.5% and offers a tumor‐specific targeted computed tomographic and photoacoustic imaging system. Furthermore, when treated with nontoxic Au NC‐Ce6, cancer cells and tumors are obliterated with low doses of irradiation and safe power levels, with both photothermal and photodynamic therapeutic effects, in vitro and vivo. These data provide a solid foundation for the clinical application of Au NC. Abstract : Multifunctional Au nanocups (NCs) are fabricated for the targeted computed tomographic and photoacoustic imaging of cancerous tumors and phototherapy. Au NCs show inherent photothermal and activatable photosensitizer properties under laser irradiation, with a photothermal conversion efficiency of 38.5%. The developed Au NC nanostructures hold great promise for clinical cancer diagnosis and therapy.