The HLA‐C*05 family allele – C*05:142. (21st June 2017)

• Record Type: Journal Article
• Authors: Rowlands, J.; Climer, T.; Harvey, C.; Williams, L.; Darke, C.
• Is Part Of: International journal of immunogenetics. Volume 44:Number 4(2017:Aug.)
• Page Start: 169
• Page End: 170
• Publication Date: 2017-06-21
• Subjects: HLA‐C*05 -- HLA‐C*05:142 -- HLA‐Cw5; Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12325
• Languages: English
• ISSNs: 1744-3121

Abstract

Summary: The sequencing of exons 2–7 of a likely new HLA‐C*05 allele identified the second example of HLA‐C*05:142, in a male UK European, within a few months of the first example being found in Germany. C*05:142 differs from C*05:01:01:01 by a single base (395G>C) in exon 3 resulting in an amino acid substitution of R108P. Comprehensive serological HLA‐Cw5 typing, using 19 antisera, indicated that C*05:142 encodes a "normal" Cw5 specificity. Failure to identify the involvement of position 108 in published HLA‐C epitopes supported this assertion. The likely HLA class I C*05:142‐bearing haplotype is A*02:01~C*05:142~B*44:02. This new allele has a maximum frequency of 0.00001, in 34, 743 sequenced‐based typed subjects, contrasting with that of C*05:01 (allele frequency 0.10441), in our local, largely UK European, blood donors.