Interleukin‐1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. (27th April 2017)

• Record Type: Journal Article
• Authors: Iracheta‐Vellve, Arvin; Petrasek, Jan; Gyogyosi, Benedek; Bala, Shashi; Csak, Timea; Kodys, Karen; Szabo, Gyongyi
• Is Part Of: Liver international. Volume 37:Number 7(2017)
• Page Start: 968
• Page End: 973
• Publication Date: 2017-04-27
• Subjects: alcoholic liver disease -- interleukin 1 -- interleukin 1 receptor antagonist -- liver regeneration; Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.13430
• Languages: English
• ISSNs: 1478-3223

Abstract

Abstract: Background & Aims: Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)‐1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL‐1 in liver regeneration in the recovery phase of alcohol‐induced liver injury is unknown. Methods: In this study, we tested IL‐1 receptor antagonist to block IL‐1 signalling in a mouse model of acute‐on‐chronic liver injury on liver inflammation and hepatocyte regeneration in AH. Results: We observed that inhibition of IL‐1 signalling decreased liver inflammation and neutrophil infiltration, and resulted in enhanced regeneration of hepatocytes and increased rate of recovery from liver injury in AH. Conclusion: Our novel findings suggest that IL‐1 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.