Non‐water‐suppressed short‐echo‐time magnetic resonance spectroscopic imaging using a concentric ring k‐space trajectory. (8th March 2017)

• Record Type: Journal Article
• Authors: Emir, Uzay E.; Burns, Brian; Chiew, Mark; Jezzard, Peter; Thomas, M. Albert
• Is Part Of: NMR in biomedicine. Volume 30:Number 7(2017:Jul.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-03-08
• Subjects: concentric rings -- metabolite‐cycling -- non‐water‐suppressed -- spectroscopic imaging; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.3714
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : Water‐suppressed MRS acquisition techniques have been the standard MRS approach used in research and for clinical scanning to date. The acquisition of a non‐water‐suppressed MRS spectrum is used for artefact correction, reconstruction of phased‐array coil data and metabolite quantification. Here, a two‐scan metabolite‐cycling magnetic resonance spectroscopic imaging (MRSI) scheme that does not use water suppression is demonstrated and evaluated. Specifically, the feasibility of acquiring and quantifying short‐echo ( T E = 14 ms), two‐dimensional stimulated echo acquisition mode (STEAM) MRSI spectra in the motor cortex is demonstrated on a 3 T MRI system. The increase in measurement time from the metabolite‐cycling is counterbalanced by a time‐efficient concentric ring k ‐space trajectory. To validate the technique, water‐suppressed MRSI acquisitions were also performed for comparison. The proposed non‐water‐suppressed metabolite‐cycling MRSI technique was tested for detection and correction of resonance frequency drifts due to subject motion and/or hardware instability, and the feasibility of high‐resolution metabolic mapping over a whole brain slice was assessed. Our results show that the metabolite spectra and estimated concentrations are in agreement between non‐water‐suppressed and water‐suppressed techniques. The achieved spectral quality, signal‐to‐noise ratio (SNR) > 20 and linewidth <7 Hz allowed reliable metabolic mapping of five major brain metabolites in the motor cortex with an in‐plane resolution of 10 × 10 mm 2 in 8 min and with a Cramér‐Rao lower bound of less than 20% using LCModel analysis. In addition, the high SNR of the water peak of the non‐water‐suppressed technique enabled voxel‐wise single‐scan frequency, phase and eddy current correction. These findings demonstrate that our non‐water‐suppressed metabolite‐cycling MRSI technique can perform robustly on 3 T MRI systems and within a clinically feasible acquisition time. Abstract : In this study, the feasibility of acquiring and quantifying short‐echo (TE = 14 ms), two‐dimensional STEAM MRSI spectra from motor cortex was demonstrated by utilising a non‐water suppressed metabolite‐cycling technique. The increase in measurement time by the metabolite‐cycling was counterbalanced by a time efficient concentric ring k‐space trajectory. The proposed novel MRSI technique will be beneficial not only for acquiring simultaneous metabolite and internal reference but also for combining phased‐array coil and correcting residual eddy currents, phase and frequency drifts.