Amniocentesis and chorionic villus sampling in HIV‐infected pregnant women: a multicentre case series. (20th June 2016)

• Record Type: Journal Article
• Authors: Floridia, M; Masuelli, G; Meloni, A; Cetin, I; Tamburrini, E; Cavaliere, AF; Dalzero, S; Sansone, M; Alberico, S; Guerra, B; Spinillo, A; Chiadò Fiorio Tin, M; Ravizza, M
• Other Names: Mori F. investigator.; Ortolani P. investigator.; dalle Nogare E.R. investigator.; Di Lorenzo F. investigator.; Sterrantino G. investigator.; Meli M. investigator.; Polemi S. investigator.; Nocentini J. investigator.; Baldini M. investigator.; Montorzi G. investigator.; Mazzetti M. investigator.; Rogasi P. investigator.; Borchi B. investigator.; Vichi F. investigator.; Del Pin B. investigator.; Pinter E. investigator.; Anzalone E. investigator.; Marocco R. investigator.; Mastroianni C. investigator.; Mercurio V.S. investigator.; Carocci A. investigator.; Grilli E. investigator.; Maccabruni A. investigator.; Zaramella M. investigator.; Mariani B. investigator.; Natalini Raponi G. investigator.; Guaraldi G. investigator.; Nardini G. investigator.; Stentarelli C. investigator.; Beghetto B. investigator.; Degli Antoni A.M. investigator.; Molinari A. investigator.; Crisalli M.P. investigator.; Donisi A. investigator.; Piepoli M. investigator.; Cerri V. investigator.; Zuccotti G. investigator.; Giacomet V. investigator.; Coletto S. investigator.; Di Nello F. investigator.; Madia C. investigator.; Placido G. investigator.; Vivarelli A. investigator.; Castelli P. investigator.; Savalli F. investigator.; Portelli V. investigator.; Sabbatini F. investigator.; Francisci D. investigator.; Bernini L. investigator.; Grossi P. investigator.; Rizzi L. investigator.; Maso G. investigator.; Airoud M. investigator.; Soppelsa G. investigator.; Dedoni M. investigator.; Cuboni C. investigator.; Ortu F. investigator.; Piano P. investigator.; Citernesi A. investigator.; Bordoni Vicini I. investigator.; Luzi K. investigator.; Roccio M. investigator.; Vimercati A. investigator.; Miccolis A. investigator.; De Gennaro A investigator.; Cervi F. investigator.; Simonazzi G. investigator.; Margarito E. investigator.; Capretti M.G. investigator.; Marsico C. investigator.; Faldella G. investigator.; Martinelli P. investigator.; Agangi A. investigator.; Capone A. investigator.; Maruotti G.M. investigator.; Tibaldi C. investigator.; Trentini L. investigator.; Todros T. investigator.; Frisina V. investigator.; Brambilla T. investigator.; Savasi V. investigator.; Personeni C. investigator.; Giaquinto C. investigator.; Fiscon M. investigator.; Rubino E. investigator.; Bucceri A. investigator.; Matrone R. investigator.; Scaravelli G. investigator.; Genovese O. investigator.; Cafforio C. investigator.; Pinnetti C. investigator.; Liuzzi G. investigator.; Tozzi V. investigator.; Massetti P. investigator.; Casadei A.M. investigator.; Cellini M. investigator.; Castelli Gattinara G. investigator.; Marconi A.M. investigator.; Sacchi V. investigator.; Ierardi M. investigator.; Polizzi C. investigator.; Mattei A. investigator.; Pirillo M.F. investigator.; Amici R. investigator.; Galluzzo C.M. investigator.; Donnini S. investigator.; Baroncelli S. investigator.; Villani P. investigator.; Cusato M. investigator.; Cerioli A. investigator.; De Martino M investigator.; Mastroiacovo P. investigator.; Parazzini F. investigator.; Vella S. investigator.;
• Is Part Of: BJOG. Volume 124:Number 8(2017)
• Page Start: 1218
• Page End: 1223
• Publication Date: 2016-06-20
• Subjects: Amniocentesis -- birth defects -- chorionic villus sampling -- HIV -- invasive testing -- mother‐to child HIV transmission -- pregnancy -- prenatal diagnosis; Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.14183
• Languages: English
• ISSNs: 1470-0328

Abstract

Abstract : Objectives: To assess in pregnant women with HIV the rates of amniocentesis and chorionic villus sampling (CVS), and the outcomes associated with such procedures. Design: Observational study. Data from the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy were used. Setting: University and hospital clinics. Population: Pregnant women with HIV. Methods: Temporal trends were analysed by analysis of variance and by the Chi‐square test for trend. Quantitative variables were compared by Student's t ‐test and categorical data by the Chi‐square test, with odds ratios and 95% confidence intervals calculated. Main outcome measures: Rate of invasive testing, intrauterine death, HIV transmission. Results: Between 2001 and 2015, among 2065 pregnancies in women with HIV, 113 (5.5%) had invasive tests performed. The procedures were conducted under antiretroviral treatment in 99 cases (87.6%), with a significant increase over time in the proportion of tests performed under highly active antiretroviral therapy (HAART) (100% in 2011–2015). Three intrauterine deaths were observed (2.6%), and 14 pregnancies were terminated because of fetal anomalies. Among 96 live newborns, eight had no information available on HIV status. Among the remaining 88 cases with either amniocentesis ( n = 75), CVS ( n = 12), or both ( n = 1), two HIV transmissions occurred (2.3%). No HIV transmission occurred among the women who were on HAART at the time of invasive testing, and none after 2005. Conclusions: The findings reinforce the assumption that invasive prenatal testing does not increase the risk of HIV vertical transmission among pregnant women under suppressive antiretroviral treatment. Tweetable abstract: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti‐HIV regimens. Tweetable abstract: No HIV transmission occurred among women who underwent amniocentesis or CVS under effective anti‐HIV regimens.