Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris. Issue 3 (June 2017)

• Record Type: Journal Article
• Authors: Miyamoto, Satoko; Ohkubo, Atsushi; Seshima, Hiroshi; Komori, Shigeto; Yamamoto, Motoki; Maeda, Takuma; Itagaki, Ayako; Yamamoto, Hiroko; Nojima, Kohei; Iimori, Soichiro; Naito, Shotaro; Kurashima, Naoki; Sohara, Eisei; Rai, Tatemitsu; Uchida, Shinichi; Okado, Tomokazu
• Other Names: Kinugasa Eriko guestEditor.
• Is Part Of: Therapeutic apheresis and dialysis. Volume 21:Issue 3(2017)
• Page Start: 226
• Page End: 231
• Publication Date: 2017-06
• Subjects: Desmoglein -- Factor XIII -- Fibrinogen -- Pemphigus vulgaris -- Selective plasma exchange; Hemapheresis -- Periodicals; Dialysis -- Periodicals; Blood Component Removal -- Periodicals; Renal Dialysis -- Periodicals; Hémaphérèse -- Périodiques; Dialyse -- Périodiques; Sang -- Collecte et conservation -- Périodiques; 616
• DOI: 10.1111/1744-9987.12555
• Languages: English
• ISSNs: 1744-9979

Abstract

Abstract: Pemphigus vulgaris is a serious autoimmune skin disorder associated with desmoglein 1 and 3. Selective plasma exchange (SePE) for pemphigus vulgaris remains unknown. We investigated the removal characteristics of pemphigus autoantibodies, immunoglobulins, and fibrinogen in three cases. When the mean processed volume for SePE was 1.2 plasma volumes, the mean percent reduction was 50.7% for desmoglein 1, 48.9% for desmoglein 3, 50.3% for IgG, 29.8% for IgA, 1.9% for IgM, and 17.6% for fibrinogen. In one case, the percent reduction after four sessions of SePE within eight days was 87.0% for desmoglein 1, 85.1% for desmoglein 3, 76.6% for IgG, 53.5% for IgA, 7.9% for IgM, 41.6% for fibrinogen, and 31.4% for factor XIII. SePE can effectively remove pemphigus autoantibodies and retain coagulation factors, e.g. factor XIII and fibrinogen. In severe cases, SePE can be useful and safe for induction therapy.