The Lipids of the Early Endosomes: Making Multimodality Work. (10th May 2017)

• Record Type: Journal Article
• Authors: Arumugam, Senthil; Kaur, Amandeep
• Is Part Of: Chembiochem. Volume 18:Number 12(2017)
• Page Start: 1053
• Page End: 1060
• Publication Date: 2017-05-10
• Subjects: cholesterol -- endosomes -- lipids -- phosphoinositides -- phospholipids; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201700046
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract: Early endosomes are dynamic intracellular compartments that fuse with incoming endocytic carrier vesicles and associated cargoes from the plasma membrane. It has been long known that the chemical structures of lipids confer striking properties and rich biochemistry on bilayers. Although the organisational principles of the plasma membrane are relatively better understood, understanding endosomal membranes has been challenging. It has become increasingly apparent that endosomal membranes, because of their lipid compositions and interactions, use distinct lipid chemistries. We discuss the biochemical and biophysical phenomena in play at the early endosomal membrane. We focus on cholesterol, phosphoinositides, and phosphatidylserine and their clear roles in endosome functions. We discuss the various principles and mechanisms underpinning how these lipids are implicated at the functional level in the working of endosomes, and we summarise early endosomes as a multimodal organelle employing distinct lipid‐specific mechanisms. Abstract : This minireview attempts to overlay the functions of distinct lipid molecules (cholesterol, phosphoinositides, and phosphatidylserine) involved in the functioning of endosomes with the Rab‐centric organisation of endosomes. We suggest that the endosomes might operate under different modalities specific to the cargoes and the lipids with which they interact.