Oxalic Acid as Sustainable CO Source for Pyrrolone‐Fused Benzosuberenes Synthesis through Palladium Catalyzed Carbonylative Cyclization. Issue 17 (13th June 2017)

• Record Type: Journal Article
• Authors: Bharti, Richa; Reddy, C. Bal; Das, Pralay
• Is Part Of: ChemistrySelect. Volume 2:Issue 17(2017)
• Page Start: 4626
• Page End: 4629
• Publication Date: 2017-06-13
• Subjects: Carbonylative cyclization -- (COOH)2. 2H2O -- Himachalene -- Palladium catalyst -- Pyrrolone fused benzosuberene; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201700592
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Oxalic acid has been used as safe, environmentally benign and operationally simple in situ CO source for the palladium catalyzed conversion of amino‐vinyl‐bromide benzocycloheptene analogues to produce the corresponding pyrrolone‐fused benzosuberenes. The present methodology describes selective intra‐molecular carbonylative cyclization strategy to generate pyrrolone‐fused tricyclic conjugate system following semi‐synthetic approaches of Himachalene, an essential oil obtained from Cedrus deodara sp . A series of pyrrolone‐fused benzosuberenes were targeted following Pd‐catalyzed carbonylative cyclization approach. Abstract : Palladium catalysed carbonylative cyclization of aminovinylbromide benzocycloheptenes were carried out using (COOH)2 2H2 O as low cost, sustainable CO source for the synthesis of pyrrolone fused benzosuberene derivatives.