Neutrophil‐mediated vascular barrier injury: Role of neutrophil extracellular traps. (April 2017)

• Record Type: Journal Article
• Authors: Meegan, Jamie E.; Yang, Xiaoyuan; Coleman, Danielle C.; Jannaway, Melanie; Yuan, Sarah Y.
• Is Part Of: Microcirculation. Volume 24:Number 3(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04
• Subjects: endothelial barrier dysfunction -- neutrophil extracellular traps -- vascular hyperpermeability; Biological transport -- Periodicals; Microcirculation -- Physiology -- Periodicals; 612.135
• DOI: 10.1111/micc.12352
• Languages: English
• ISSNs: 1073-9688

Abstract

Abstract: Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil–endothelium cross talk. This review highlights recent research findings about neutrophil‐mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.