Photobiomodulation with non-thermal lasers: Mechanisms of action and therapeutic uses in dermatology and aesthetic medicine. (19th May 2017) - Nestor, Mark
ABSTRACT: Background : Non-thermal laser therapy in dermatology, is a growing field in medical technology by which therapeutic effects are achieved by exposing tissues to specific wavelengths of light.Objectives : The purpose of this review was to gain a better understanding of the science behind non-thermal laser and the evidence supporting its use in dermatology.Methods : A group of dermatologists and surgeons recently convened to review the evidence supporting the use of non-thermal laser for body sculpting, improving the appearance of cellulite, and treating onychomycosis.Results : The use of non-thermal laser for body sculpting is supported by three randomized, double-blind, sham-controlled studies ( N = 161), one prospective open-label study ( N = 54), and two retrospective studies ( N = 775). Non-thermal laser application for improving the appearance of cellulite is supported by one randomized, double-blind, sham-controlled study ( N = 38). The use of non-thermal laser for the treatment of onychomycosis is supported by an analysis of three non-randomized, open-label studies demonstrating clinical improvement of nails ( N = 292).Conclusions : Non-thermal laser is steadily moving into mainstream medical practice, such as dermatology. Although present studies have demonstrated the safety and efficacy of non-thermal laser for body sculpting, cellulite reduction and onychomycosis treatment, studies demonstrating the efficacy of non-thermal laser as a stand-alone procedure are still inadequate.