Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids. Issue 12 (22nd May 2017)

• Record Type: Journal Article
• Authors: Ross, Caroline; Knox, Caroline; Tastan Bishop, Özlem
• Is Part Of: FEBS letters. Volume 591:Issue 12(2017)
• Page Start: 1687
• Page End: 1701
• Publication Date: 2017-05-22
• Subjects: alanine scan -- conserved motifs -- Enterovirus -- RNA release -- structural proteins; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12663
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Enteroviruses are responsible for a multitude of human diseases. Expansion of the virus capsid is associated with a cascade of conformational changes that allow the subsequent release of RNA. For the first time, this study presents a comprehensive bioinformatic screen for the prediction of interacting motifs within intraprotomer interfaces and across respective interfaces surrounding the fivefold and twofold axes. The results identify a network of conserved motif residues involved in interactions in enteroviruses that may be critical to capsid stabilisation, providing guidelines towards developing antivirals that interfere with viral expansion during RNA release. Abstract :