Tissue Engineering: Engineered 3D Cardiac Fibrotic Tissue to Study Fibrotic Remodeling (Adv. Healthcare Mater. 11/2017). Issue 11 (7th June 2017)

• Record Type: Journal Article
• Authors: Sadeghi, Amir Hossein; Shin, Su Ryon; Deddens, Janine C.; Fratta, Giuseppe; Mandla, Serena; Yazdi, Iman K.; Prakash, Gyan; Antona, Silvia; Demarchi, Danilo; Buijsrogge, Marc P.; Sluijter, Joost P. G.; Hjortnaes, Jesper; Khademhosseini, Ali
• Is Part Of: Advanced healthcare materials. Volume 6:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-06-07
• Subjects: cardiac fibrosis -- cardiac tissue engineering -- hydrogels -- in vitro 3D models -- myofibroblast; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201770054
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Ali Khademhosseini and co‐workers describe an engineered 3D fibrotic heart tissue, which is created by fabricating physiologically relevant cardiac tissues with native‐like mechanical properties in article number1601434 . Upon exogenous stimulation with profibrotic transforming growth factor beta‐1, these tissues reveal fibrogenic changes, such as collagen production, myofibroblast activation, and electrophysiological disturbances.