Microfluidic Encapsulation of Prickly Zinc‐Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy. Issue 11 (8th March 2017)

• Record Type: Journal Article
• Authors: Zhang, Hongbo; Liu, Dongfei; Wang, Liang; Liu, Zehua; Wu, Runrun; Janoniene, Agne; Ma, Ming; Pan, Guoqing; Baranauskiene, Lina; Zhang, Linlin; Cui, Wenguo; Petrikaite, Vilma; Matulis, Daumantas; Zhao, Hongxia; Pan, Jianming; Santos, Hélder A.
• Is Part Of: Advanced healthcare materials. Volume 6:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-03-08
• Subjects: acetalated dextran -- microfluidic -- mitochondria -- targeted cancer therapy -- Zn‐doped CuO; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201601406
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Structural features of nanoparticles have recently been explored for different types of applications. To explore specific particles as nanomedicine and physically destroy cancer is interesting, which might avoid many obstacles in cancer treatment, for example, drug resistance. However, one key element and technical challenge of those systems is to selectively target them to cancer cells. As a proof‐of‐concept, Prickly zinc‐doped copper oxide (Zn–CuO) nanoparticles (Prickly NPs) have been synthesized, and subsequently encapsulated in a pH‐responsive polymer; and the surface has been modified with a novel synthesized ligand, 3‐(cyclooctylamino)‐2, 5, 6‐trifluoro‐4‐[(2‐hydroxyethyl)sulfonyl] benzenesulfonamide (VD1142). The Prickly NPs exhibit very effective cancer cell antiproliferative capability. Moreover, the polymer encapsulation shields the Prickly NPs from unspecific nanopiercing and, most importantly, VD1142 endows the engineered NPs to specifically target to the carbonic anhydrase IX, a transmembrane protein overexpressed in a wide variety of cancer tumors. Intracellularly, the Prickly NPs disintegrate into small pieces that upon endosomal escape cause severe damage to the endoplasmic reticulum and mitochondria of the cells. The engineered Prickly NP is promising in efficient and targeted cancer treatment and it opens new avenue in nanomedication. Abstract : Prickly Zn–CuO nanoparticles are engineered and encapsulated in spermine modified acetalated dextran nanomatrix, and further conjugated with VD1142 for enhancing the targeting and antiproliferative effect in carbonic anhydrase IX expressing cancer cells. The cell death is mainly induced by direct nanopiercing and destruction of the intracellular organelles, which offers several advantages and overcomes the traditional obstacles in drug based systems.