The pancreatic cancer microenvironment: A true double agent. Issue 1 (12th June 2017)

• Record Type: Journal Article
• Authors: Melstrom, Laleh G.; Salazar, Marcela D.; Diamond, Don J.
• Other Names: Melstrom Laleh G. guestEditor.; Singh Gagandeep guestEditor.; Fong Yuman guestEditor.
• Is Part Of: Journal of surgical oncology. Volume 116:Issue 1(2017)
• Page Start: 7
• Page End: 15
• Publication Date: 2017-06-12
• Subjects: focal adhesion kinase -- hedgehog inhibitors -- hyaluronan -- immunotherapy -- tumor microenvironment -- vitamin D; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.24643
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract : The tumor microenvironment in pancreatic cancer is a complex balance of pro‐ and anti‐tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C‐X‐C motif) receptor 4 (CXCR‐4), immunotherapy, and Vitamin D. The developing clinical therapeutics will be reviewed.