Infectious complications in patients with myelodysplastic syndromes: A review of the literature with emphasis on patients treated with 5‐azacitidine. (20th April 2017)

• Record Type: Journal Article
• Authors: Radsak, Markus; Platzbecker, Uwe; Schmidt, Cornelia S.; Hofmann, Wolf‐Karsten; Nolte, Florian
• Is Part Of: European journal of haematology. Volume 99:Number 2(2017)
• Page Start: 112
• Page End: 118
• Publication Date: 2017-04-20
• Subjects: 5‐azacitidine -- infection -- myelodysplastic syndromes -- supportive care -- socioeconomics and ethics; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.12883
• Languages: English
• ISSNs: 0902-4441

Abstract

Abstract: Myelodysplastic Syndromes are oligo‐clonal stem cell disorders that are associated with cytopenias in the peripheral blood. Major causes for morbidity and mortality in myelodysplastic syndromes (MDS) patients are infections mostly due to bacteria or fungi. Beside leucopenia per se in affected patients, function of white blood cells particularly that of neutrophils seems to be impaired. Here we summarize the available data on infections in MDS patients in general and particularly those treated with 5‐azacitidine.