Lewis Acid‐Catalyzed C(sp3)–C(sp3) Bond Forming Cyclization Reactions for the Synthesis of Tetrahydroprotoberberine Derivatives. Issue 13 (4th May 2017)

• Record Type: Journal Article
• Authors: Li, Jianjun; Qin, Cong; Yu, Yang; Fan, Huaqiang; Fu, Yiwei; Li, Hao; Wang, Wei
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 13(2017)
• Page Start: 2191
• Page End: 2195
• Publication Date: 2017-05-04
• Subjects: annulation -- azaarene activation -- C(sp3)–C(sp3) bond formation -- Lewis acid catalysis -- tetrahydroprotoberberine derivatives; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201601423
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient Lewis acid‐catalyzed C( sp 3 )–C( sp 3 ) bond forming annulation reaction has been developed. This strategy serves as a new method for the facile synthesis of tetrahydro‐5 H ‐isoquinolino[2, 1‐ g ][1, 6]naphthyridine derivatives. A wide range of 2‐methylquinoline‐3‐carbaldehydes and 1, 2, 3, 4‐tetrahydroisoquinolines can be applied for this process to afford structurally diverse tetrahydroprotoberberine derivatives in excellent yields. Abstract :